Tacrolimus — impurities and related standards

All 4 Tacrolimus-related compounds in the CATO catalogue, listed with their CAS numbers, molecular formulae and stock status. If the compound you need is not listed, send the structure or the impurity designation and we will check whether it can be synthesised or isolated.

Tacrolimus is a macrolide immunosuppressant produced by Streptomyces tsukubaensis and used to prevent rejection after organ transplantation. Because it is obtained by fermentation, its impurity profile is populated by related macrolides: desmethyl and other biosynthetic analogues, epimers at the hemiketal centre, and hydrolysis or oxidation products that arise during isolation and storage. Laboratories analysing tacrolimus and its formulations therefore depend on individually characterised congener standards. The page lists the EP-designated tacrolimus impurities as separate, structurally defined lots, suitable for pharmacopoeial related-substance testing, peak identification in impurity profiles, and separation-method development for this closely related family of macrolides.

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